From our live chat data, three of the frequently asked questions are
What are the benefits of Agarwood oil?
How do I use Agarwood oils?
How much agarwood oil is usually put into a perfume?
So today, I will answer those questions with some recent Agarwood related journals.
Agarwood essential oil, also known as oud oil, is extracted from the agarwood tree and carries an exceptional fragrance. In addition to its pleasant smell, it offers a number of beneficial health properties! Here are some of them::
Relaxation and stress relief:
The warm, woody scent of agarwood essential oil is known to be calming and relaxing, making it an effective remedy for stress, anxiety, and insomnia.
Alamil (et al 2022) in Rediscovering the Therapeutic Potential of Agarwood in the Management of Chronic Inflammatory Diseases has summarised some important points.
The researchers observed that agarwood has anti-inflammatory properties in rats with inflammation in the liver or brain induced by methanol injection. This was shown to bring proinflammatory mediators and neurotransmitters back to near-normal levels through the inhibition of multiple inflammatory pathways. Other studies have also found that agarwood has strong antidepressant and anxiolytic effects on stressed rats, believed to be due to the inhibition and downregulation of cytokines (IL-1α, IL-1β, and IL-6) that activate the HPA axis and lead to depression and anxiety
The second study used rats and found that agarwood has strong anti-depressant and anti-stress effects. This was evidenced by reduced levels of various markers, including lipid peroxidation, NO, TNF-α, IL-1β, cortisol, COX-2, LOX, AST, ALT, and lipids. The study suggests that these effects are primarily due to the suppression of cortisol, which leads to the suppression of these cytokines.
Recent studies have shown that the neuroimmune-endocrine axis plays a significant role in depression and anxiety. Stressful triggers in the brain lead to the release of inflammatory cytokines such as IL-1β, IL-6, and TNF-α, which affect neurotransmitter and hormonal balance in the HPA axis and cause emotional imbalance and symptoms of depression and anxiety. Prolonged stress also leads to neuronal damage and further activation of inflammatory pathways and mediators, such as NO, PGE, and COX. Therefore, agarwood oil is a potential candidate for a new treatment for both diseases that avoids the side effects of conventional treatments.
Agarwood oil can help you to relax and relieve your stress. However, it cannot get rid of your worries completely. I use Oud oil daily but some days no matter how much oil I use, I still feel stressed.
So I seek help. A local monk told me to ask myself
" Can I do something about it?"
"Yes, I can." <- ok, since I can do something about it, why should I worry?
"No, I cannot." <- there is nothing I can do, so there is no point to worry.
This was an eye-opening and profound lesson I learnt and I would like to share it with you
Understanding this will truly reduce your worries and stress even if you do not use Agarwood oil :)
Agarwood essential oil has anti-inflammatory properties that can help to relieve pain and discomfort, particularly in the joints and muscles.
The below table will summarise the anti-inflammatory properties of Oud oil
In vivo and in vitro study on carrageenan-induced rat paw edema and HRBC stabilization method
In vivo: 50 and 100 mg/kg
In vivo: 4 h
Inhibition of the cyclooxygenase (COX) inflammatory pathway
Strong inhibition of rat paw edema. Inhibition of the release of prostaglandins. HRBC membrane stabilization.
Agarwood essential oil is often used to treat respiratory conditions such as coughs, colds, and asthma due to its decongestant properties.
According to modern pharmacology, sesquiterpene components of agarwood oil have good biological activity in the central nervous system, respiratory system, digestive system, and other systems
Agarwood oil has the potential to target certain pathways in the lungs that are related to inflammatory diseases like asthma and COPD. These pathways play a role in the pathophysiology of these conditions and may be targeted for therapeutic purposes.
NF-κB is a pathway that is activated by various inflammatory mediators, pollutants, and other factors. It has been implicated in the development of asthma and COPD. By targeting NF-κB, agarwood oil may have the potential to reduce inflammation in the lungs and improve symptoms of these conditions.
Similarly, the p38 MAPK pathway is another target for the treatment of inflammatory diseases like COPD. By blocking this pathway, agarwood oil may have the potential to reduce inflammation and improve symptoms in individuals with COPD.
In addition to targeting these pathways, agarwood oil has also been shown to block histamine release from mast cells in rats. Histamine is a substance that is released during an allergic reaction and can cause symptoms like itching, redness, and swelling. By blocking histamine release, agarwood oil may have the potential to reduce symptoms in individuals with allergy-related diseases like asthma.
Overall, while more research is needed to fully understand the effects of agarwood oil on respiratory cells and tissues, these initial findings suggest that it may have potential as a therapeutic agent for the treatment of inflammatory lung conditions like asthma and COPD.. However, more research is needed to study the direct effect of agarwood oil on respiratory cells or tissue.
Antibacterial and antifungal properties:
Without these two properties, Aquilaria trees will never turn into Agarwood.
Reason: when insects (and/or other external factors) attack the tree. Bacteria and fungi grow around the wound of the Aquilaria trees.
The trees then create "Agarwood" to fight against these invaders.
When Agarwood is distilled into Agarwood oil, the potent antibacterial and antifungal properties remain.
It means that if cosmetic manufacturers use Agarwood oil to create their skincare or perfume, the antifungal and antibacterial properties would be helpful. Their product shelf lives could be extended longer.
It is useful to include Agarwood oil in skin care products to help treat various skin conditions such as acne, fungal infections, and skin irritation.
Aromatherapy: Agarwood oil can be used in aromatherapy to help purify the air, boost the immune system, and promote overall health and well-being.
The above article is discussing the potential benefits of agarwood in treating gingivitis, a type of gum disease caused by chronic inflammation of the gums due to long-term stimulation by bacteria. It explains that gingivitis is an immune disease that occurs as a result of an imbalanced immune response to bacteria in the gums.
Agarwood and its essential oil have been found to have various pharmacological activities, including immune regulation. The essential oil has been found to have anti-inflammatory properties, which could be useful in treating gingivitis. It mentions that two substances in agarwood essential oil, tryptone and sesquiterpene, are the main anti-inflammatory and immunoreactive substances.
Two other compounds, CYF-2 and HHX-5, have been isolated from agarwood and found to inhibit the activation of certain cells involved in the immune response, such as microglia, dendritic cells, neutrophils, macrophages, T cells, and B cells. They do so by inhibiting the activation of signalling pathways in the cells, such as STAT and NF-κB.
In conclusion, the author suggests that agarwood has the potential to alleviate the overactive immune response that causes gingivitis, due to its ability to regulate the immune system and reduce inflammation.
Agarwood has some active health-beneficial compounds such as sesquiterpenoids, flavonoids, and quercetin. These active compounds have anti-inflammatory, antioxidant, bacteriostatic, analgesic, sedative, and immune properties. Gingivitis is a chronic inflammation caused by plaque accumulation on the gingival margin, and there is a need to find drugs with fewer side effects to alleviate inflammation. Agarwood has fewer side effects than commonly used chemical synthetic drugs and can potentially alleviate periodontal tissue inflammation. This paper discusses the possible mechanism of agarwood's effects and provides a theoretical basis for the transformation of the agarwood industry.